| EC |
1.1.1.439 |
| Accepted name: |
17-dehydrostemmadenine reductase |
| Reaction: |
stemmadenine + NADP+ = 17-dehydrostemmadenine + NADPH + H+ |
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For diagram of biosythesis of stemmadenine and related alkaloids, click here |
| Other name(s): |
Redox2 |
| Systematic name: |
stemmadenine:NADP+ 17-oxidoreductase |
| Comments: |
The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a biosynthetic pathway that leads to production of the bisindole alkaloid compounds vinblastine and vincristine, which are used as anticancer drugs. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Qu, Y., Easson, M.EA.M., Simionescu, R., Hajicek, J., Thamm, A.MK., Salim, V. and De Luca, V. Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine. Proc. Natl. Acad. Sci. USA 115 (2018) 3180–3185. [DOI] [PMID: 29511102] |
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| [EC 1.1.1.439 created 2024] |
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