| EC |
6.5.1.4 |
| Accepted name: |
RNA-3′-phosphate cyclase |
| Reaction: |
ATP + RNA 3′-terminal-phosphate = AMP + diphosphate + RNA terminal-2′,3′-cyclic-phosphate |
| Other name(s): |
RNA cyclase |
| Systematic name: |
RNA-3′-phosphate:RNA ligase (cyclizing, AMP-forming) |
| Comments: |
Adenosine 5′-(γ-thio)triphosphate can act instead of ATP. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, METACYC, PDB, CAS registry number: 85638-41-1 |
| References: |
| 1. |
Filipowicz, W., Konarska, M., Gross, H.J. and Shatkin, A.J. RNA 3′-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract. Nucleic Acids Res. 11 (1983) 1405–1418. [PMID: 6828385] |
| 2. |
Reinberg, D., Arenas, J. and Hurwitz, J. The enzymatic conversion of 3′-phosphate terminated RNA chains to 2′,3′-cyclic phosphate derivatives. J. Biol. Chem. 260 (1985) 6088–6097. [PMID: 2581947] |
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| [EC 6.5.1.4 created 1986, modified 1989] |
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