The Enzyme Database

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EC 6.5.1.4     
Accepted name: RNA 3′-terminal-phosphate cyclase (ATP)
Reaction: ATP + RNA 3′-terminal-phosphate = AMP + diphosphate + RNA terminal-2′,3′-cyclic-phosphate
Other name(s): RNA cyclase (ambiguous); RNA-3′-phosphate cyclase (ambiguous)
Systematic name: RNA-3′-phosphate:RNA ligase (cyclizing, AMP-forming)
Comments: Adenosine 5′-(γ-thio)triphosphate can act instead of ATP. cf. EC 6.5.1.5, RNA-3′-phosphate cyclase (GTP).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 85638-41-1
References:
1.  Filipowicz, W., Konarska, M., Gross, H.J. and Shatkin, A.J. RNA 3′-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract. Nucleic Acids Res. 11 (1983) 1405–1418. [PMID: 6828385]
2.  Reinberg, D., Arenas, J. and Hurwitz, J. The enzymatic conversion of 3′-phosphate terminated RNA chains to 2′,3′-cyclic phosphate derivatives. J. Biol. Chem. 260 (1985) 6088–6097. [PMID: 2581947]
[EC 6.5.1.4 created 1986, modified 1989, modified 2013]
 
 


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