A key enzyme in the production of coenzyme A. The bacterial enzyme requires CTP, in contrast to the eukaryotic enzyme, EC 188.8.131.52, which requires ATP. Cysteine can be replaced by some of its derivatives.
Brown, G.M. The metabolism of pantothenic acid. J. Biol. Chem.234 (1959) 370–378. [PMID: 13630913]
Strauss, E., Kinsland, C., Ge, Y., McLafferty, F.W. and Begley, T.P. Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified Coenzyme A biosynthetic enzymes in bacteria. J. Biol. Chem.276 (2001) 13513–13516. [DOI] [PMID: 11278255]
Kupke, T. Molecular characterization of the 4′-phosphopantothenoylcysteine synthetase domain of bacterial Dfp flavoproteins. J. Biol. Chem.277 (2002) 36137–36145. [DOI] [PMID: 12140293]
[EC 184.108.40.206 created 1961, modified 2003, modified 2017]