The Enzyme Database

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EC 6.3.2.5     
Accepted name: phosphopantothenate—cysteine ligase
Reaction: CTP + (R)-4′-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4′-phosphopantothenoyl]-L-cysteine
For diagram of the late stages of CoA biosynthesis, click here
Other name(s): phosphopantothenoylcysteine synthetase
Systematic name: (R)-4′-phosphopantothenate:L-cysteine ligase
Comments: Cysteine can be replaced by some of its derivatives.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9023-50-1
References:
1.  Brown, G.M. The metabolism of pantothenic acid. J. Biol. Chem. 234 (1959) 370–378. [PMID: 13630913]
2.  Strauss, E., Kinsland, C., Ge, Y., McLafferty, F.W. and Begley, T.P. Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified Coenzyme A biosynthetic enzymes in bacteria. J. Biol. Chem. 276 (2001) 13513–13516. [PMID: 11278255]
3.  Kupke, T. Molecular characterization of the 4′-phosphopantothenoylcysteine synthetase domain of bacterial Dfp flavoproteins. J. Biol. Chem. 277 (2002) 36137–36145. [PMID: 12140293]
[EC 6.3.2.5 created 1961, modified 2003]
 
 


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