The Enzyme Database

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EC 5.1.3.11     
Accepted name: cellobiose epimerase
Reaction: cellobiose = 4-O-β-D-glucopyranosyl-D-mannose
Glossary: cellobiose = 4-O-β-D-glucopyranosyl-D-glucose
Systematic name: cellobiose 2-epimerase
Comments: The enzyme catalyses the interconversion between D-glucose and D-mannose residues at the reducing end of β-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37318-37-9
References:
1.  Tyler, T.R. and Leatherwood, J.M. Epimerization of disaccharides by enzyme preparations from Ruminococcus albus. Arch. Biochem. Biophys. 119 (1967) 363–367. [PMID: 6069974]
2.  Ito, S., Taguchi, H., Hamada, S., Kawauchi, S., Ito, H., Senoura, T., Watanabe, J., Nishimukai, M., Ito, S. and Matsui, H. Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme. Appl. Microbiol. Biotechnol. 79 (2008) 433–441. [PMID: 18392616]
3.  Fujiwara, T., Saburi, W., Inoue, S., Mori, H., Matsui, H., Tanaka, I. and Yao, M. Crystal structure of Ruminococcus albus cellobiose 2-epimerase: structural insights into epimerization of unmodified sugar. FEBS Lett. 587 (2013) 840–846. [PMID: 23462136]
[EC 5.1.3.11 created 1972]
 
 


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