The Enzyme Database

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EC 4.6.1.1     
Accepted name: adenylate cyclase
Reaction: ATP = 3′,5′-cyclic AMP + diphosphate
Other name(s): adenylylcyclase; adenyl cyclase; 3′,5′-cyclic AMP synthetase; ATP diphosphate-lyase (cyclizing)
Systematic name: ATP diphosphate-lyase (cyclizing; 3′,5′-cyclic-AMP-forming)
Comments: Also acts on dATP to form 3′,5′-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+—arginine ADP-ribosyltransferase.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9012-42-4
References:
1.  Hirata, M. and Hayaishi, O. Adenyl cyclase of Brevibacterium liquefaciens. Biochim. Biophys Acta 149 (1967) 1–11. [PMID: 4295782]
[EC 4.6.1.1 created 1972]
 
 


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