The Enzyme Database

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EC 4.2.3.8     
Accepted name: casbene synthase
Reaction: geranylgeranyl diphosphate = casbene + diphosphate
For diagram of the biosynthesis of cembrene and casbene, click here
Other name(s): casbene synthetase; geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)
Comments: The enzyme from castor bean (Ricinus communis) produces the antifungal diterpene casbene.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 69106-45-2
References:
1.  Moesta, P. and West, C.A. Casbene synthetase: regulation of phytoalexin biosynthesis in Ricinus communis L. seedlings. Purification of casbene synthetase and regulation of its biosynthesis during elicitation. Arch. Biochem. Biophys. 238 (1985) 325–333. [PMID: 3985625]
[EC 4.2.3.8 created 1989 as EC 4.6.1.7, transferred 2000 to EC 4.2.3.8]
 
 


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