The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: sclareol synthase
Reaction: (13E)-8α-hydroxylabd-13-en-15-yl diphosphate + H2O = sclareol + diphosphate
For diagram of labdane, pimarane and phyllocadane diterpenoids biosynthesis, click here
Glossary: sclareol = (13R)-labd-14-ene-8α,13-diol
(13E)-8α-hydroxylabd-13-en-15-yl diphosphate = copal-8-ol diphosphate
Other name(s): SS
Systematic name: (13E)-8α-hydroxylabd-13-en-15-yl-diphosphate-lyase (sclareol forming)
Comments: Isolated from the plant Salvia sclarea (clary sage). Originally thought to be synthesized in one step from geranylgeranyl diphosphate it is now known to require two enzymes, EC, copal-8-ol diphosphate synthase and EC, sclareol synthase. Sclareol is used in perfumery.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Caniard, A., Zerbe, P., Legrand, S., Cohade, A., Valot, N., Magnard, J.L., Bohlmann, J. and Legendre, L. Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture. BMC Plant Biol. 12:119 (2012). [PMID: 22834731]
[EC created 2013]

Data © 2001–2016 IUBMB
Web site © 2005–2016 Andrew McDonald