The Enzyme Database

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EC 4.2.3.134     
Accepted name: 5-phosphonooxy-L-lysine phospho-lyase
Reaction: (5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH3 + phosphate
Other name(s): 5-phosphohydroxy-L-lysine ammoniophospholyase; AGXT2L2 (gene name); (5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)
Systematic name: (5R)-5-phosphooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)
Comments: A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC 4.2.3.2, ethanolamine-phosphate phospho-lyase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Tsai, C.H. and Henderson, L.M. Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase. J. Biol. Chem. 249 (1974) 5784–5789. [PMID: 4412716]
2.  Veiga-da-Cunha, M., Hadi, F., Balligand, T., Stroobant, V. and Van Schaftingen, E. Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. J. Biol. Chem. 287 (2012) 7246–7255. [PMID: 22241472]
[EC 4.2.3.134 created 2012]
 
 


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