The Enzyme Database

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EC 4.2.3.126     
Accepted name: γ-muurolene synthase
Reaction: (2E,6E)-farnesyl diphosphate = γ-muurolene + diphosphate
For diagram of cadinane sesquiterpenoid biosynthesis, click here
Glossary: γ-muurolene = (1S,4aS,8aR)-1-isopropyl-7-methyl-4-methylene-1,2,3,4,4a,5,6,8a-octahydronaphthalene
Other name(s): Cop3
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lase (cyclizing, γ-muurolene-forming)
Comments: The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and α-muurolene, see EC 4.2.3.23, germacrene-A synthase and EC 4.2.3.125, α-muurolene synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Agger, S., Lopez-Gallego, F. and Schmidt-Dannert, C. Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus. Mol. Microbiol. 72 (2009) 1181–1195. [PMID: 19400802]
2.  Lopez-Gallego, F., Wawrzyn, G.T. and Schmidt-Dannert, C. Selectivity of fungal sesquiterpene synthases: role of the active site’s H-1α loop in catalysis. Appl. Environ. Microbiol. 76 (2010) 7723–7733. [PMID: 20889795]
[EC 4.2.3.126 created 2012]
 
 


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