The Enzyme Database

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EC 4.2.3.11     
Accepted name: sabinene-hydrate synthase
Reaction: geranyl diphosphate + H2O = sabinene hydrate + diphosphate
For diagram of monoterpenoid biosynthesis, click here
Other name(s): sabinene hydrate cyclase
Systematic name: geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)
Comments: Both cis- and trans- isomers of sabinene hydrate are formed. (3R)-Linalyl diphosphate is an intermediate in the reaction
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 117164-95-1
References:
1.  Hallahan, T.W. and Croteau, R. Monoterpene biosynthesis: demonstration of a geranyl pyrophosphate:sabinene hydrate cyclase in soluble enzyme preparations from sweet marjoram (Majorana hortensis). Arch. Biochem. Biophys. 264 (1988) 618–631. [DOI] [PMID: 3401015]
2.  Hallahan, T.W. and Croteau, R. Monoterpene biosynthesis: mechanism and stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (+)-cis- and (+)-trans-sabinene hydrate. Arch. Biochem. Biophys. 269 (1989) 313–326. [DOI] [PMID: 2916845]
[EC 4.2.3.11 created 1992 as EC 4.6.1.9, transferred 2000 to EC 4.2.3.11]
 
 


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