The Enzyme Database

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EC 4.2.3.10     
Accepted name: (-)-endo-fenchol synthase
Reaction: geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate
For diagram of monoterpenoid biosynthesis, click here
Other name(s): (-)-endo-fenchol cyclase; geranyl pyrophosphate:(-)-endo-fenchol cyclase
Systematic name: geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]
Comments: (3R)-Linalyl diphosphate is an intermediate in the reaction
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 117758-41-5
References:
1.  Croteau, R., Miyazaki, J.H. and Wheeler, C.J. Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(-)-endo-fenchol cyclase from fennel (Foeniculum vulgare). Arch. Biochem. Biophys. 269 (1989) 507–516. [PMID: 2919880]
2.  Croteau, R., Satterwhite, D.M., Wheeler, C.J. and Felton, N.M. Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (-)-endo-fenchol. J. Biol. Chem. 263 (1988) 15449–15453. [PMID: 3170591]
[EC 4.2.3.10 created 1992 as EC 4.6.1.8, transferred 2000 to EC 4.2.3.10]
 
 


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