| EC |
3.6.5.5 |
| Accepted name: |
dynamin GTPase |
| Reaction: |
GTP + H2O = GDP + phosphate |
| Systematic name: |
GTP phosphohydrolase (vesicle-releasing) |
| Comments: |
An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Warnock, D.E. and Schmid, S.L. Dynamin GTPase, a force-generating molecular switch. Bioessays 18 (1996) 885–893. [DOI] [PMID: 8939066] |
| 2. |
McClure, S.J. and Robinson, P.J. Dynamin, endocytosis and intracellular signalling. Mol. Membr. Biol. 13 (1996) 189–215. [PMID: 9116759] |
| 3. |
Oh, P., McIntosh, D.P. and Schnitzer, J.E. Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium. J. Cell Biol. 141 (1998) 101–114. [PMID: 9531551] |
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| [EC 3.6.5.5 created 2000 as EC 3.6.1.50, transferred 2003 to EC 3.6.5.5] |
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