Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15-27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction.
Rayment, I. The structural basis of myosin ATPase activity. J. Biol. Chem.271 (1996) 15850–15853. [DOI] [PMID: 8663496]
Hasson, T. and Mooseker, M.S. Vertebrate unconventional myosins. J. Biol. Chem.271 (1996) 16431–16434. [DOI] [PMID: 8690736]
Murphy, C.T. and Spudich, J.A. The sequence of the myosin 50-20K loop affects myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity. Biochemistry38 (1999) 3785–3792. [DOI] [PMID: 10090768]
[EC 220.127.116.11 created 1984 as EC 18.104.22.168, transferred 2000 to EC 22.214.171.124]