| EC |
3.6.3.9 |
| Accepted name: |
Na+/K+-exchanging ATPase |
| Reaction: |
ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in |
| Systematic name: |
ATP phosphohydrolase (Na+/K+-exchanging) |
| Comments: |
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Skou, J.C. The influence of some cations on an adenosinetriphosphatase from peripheral nerve. Biochim. Biophys. Acta 23 (1957) 394–401. [DOI] [PMID: 13412736] |
| 2. |
Post, R.L., Sen, A.K. and Rosenthal, A.S. A phosphorylated intermediate in adenosine triphosphate-dependent sodium and potassium transport across kidney membrane. J. Biol. Chem. 240 (1965) 1437–1445. [PMID: 14284759] |
| 3. |
Skou, J.C. The energy-coupled exchange of Na+ for K+ across the cell membrane. The Na+,K+ pump. FEBS Lett. 268 (1990) 314–324. [DOI] [PMID: 2166689] |
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| [EC 3.6.3.9 created 1984 as EC 3.6.1.37, transferred 2000 to EC 3.6.3.9, modified 2001] |
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