ExplorEnz: EC 3.6.1.77

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3.6.1.77

Accepted name:

coenzyme A diphosphatase

Reaction:

coenzyme A + H₂O = adenosine 3′,5′-bisphosphate + 4′-phosphopantetheine

Other name(s):

CoA pyrophosphatase; coenzyme A pyrophosphatase; CoA diphosphohydrolase; Nudt19; Nudt7; thnR (gene name)

Systematic name:

coenzyme A 4′-phosphopantetheine phosphohydrolase

Comments:

The enzyme belongs to the Nudix hydrolase family. It has been reported from bacteria, yeast, and mammals. Activity is higher with oxidized disulfide CoA than with reduced CoA.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Xu, W., Shen, J., Dunn, C.A., Desai, S. and Bessman, M.J. The Nudix hydrolases of Deinococcus radiodurans. Mol. Microbiol. 39 (2001) 286–290. [DOI] [PMID: 11136450]
2.	Gasmi, L. and McLennan, A.G. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. Biochem. J. 357 (2001) 33–38. [DOI] [PMID: 11415433]
3.	Kang, L.W., Gabelli, S.B., Bianchet, M.A., Xu, W.L., Bessman, M.J. and Amzel, L.M. Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family. J. Bacteriol. 185 (2003) 4110–4118. [DOI] [PMID: 12837785]
4.	Freeman, M.F., Moshos, K.A., Bodner, M.J., Li, R. and Townsend, C.A. Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis. Proc. Natl. Acad. Sci. USA 105 (2008) 11128–11133. [DOI] [PMID: 18678912]
5.	Shumar, S.A., Kerr, E.W., Geldenhuys, W.J., Montgomery, G.E., Fagone, P., Thirawatananond, P., Saavedra, H., Gabelli, S.B. and Leonardi, R. Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform. J. Biol. Chem. 293 (2018) 4134–4148. [DOI] [PMID: 29378847]

[EC 3.6.1.77 created 2024]