ExplorEnz: EC 3.6.1.6

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3.6.1.6

Accepted name:

nucleoside diphosphate phosphatase

Reaction:

a nucleoside diphosphate + H₂O = a nucleoside phosphate + phosphate

Other name(s):

nucleoside-diphosphatase; thiaminpyrophosphatase; UDPase; inosine diphosphatase; adenosine diphosphatase; IDPase; ADPase; adenosinepyrophosphatase; guanosine diphosphatase; guanosine 5′-diphosphatase; inosine 5′-diphosphatase; uridine diphosphatase; uridine 5′-diphosphatase; type B nucleoside diphosphatase; GDPase; CDPase; nucleoside 5′-diphosphatase; type L nucleoside diphosphatase; NDPase; nucleoside diphosphate phosphohydrolase

Systematic name:

nucleoside-diphosphate phosphohydrolase

Comments:

The enzyme, which appears to be limited to metazoa, acts on multiple nucleoside diphosphates as well as on D-ribose 5-diphosphate. Specificity depends on species and isoform.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9027-69-4

References:

1.	Gibson, D.M., Ayengar, P. and Sanadi, D.R. A phosphatase specific for nucleoside diphosphates. Biochim. Biophys. Acta 16 (1955) 536–538. [DOI] [PMID: 14389272]
2.	Horecker, B.L., Hurwitz, J. and Heppel, L.A. The synthesis of ribose 5-pyrophosphate and ribose 5-triphosphate. J. Am. Chem. Soc. 79 (1957) 701–702.
3.	Yeung, G., Mulero, J.J., McGowan, D.W., Bajwa, S.S. and Ford, J.E. CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart. Biochemistry 39 (2000) 12916–12923. [DOI] [PMID: 11041856]
4.	Failer, B.U., Braun, N. and Zimmermann, H. Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase. J. Biol. Chem. 277 (2002) 36978–36986. [DOI] [PMID: 12167635]
5.	Uccelletti, D., O'Callaghan, C., Berninsone, P., Zemtseva, I., Abeijon, C. and Hirschberg, C.B. ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans. J. Biol. Chem. 279 (2004) 27390–27398. [DOI] [PMID: 15102851]

[EC 3.6.1.6 created 1961]