The Enzyme Database

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EC 3.5.4.35     
Accepted name: tRNA(cytosine8) deaminase
Reaction: cytosine8 in tRNA + H2O = uracil8 in tRNA + NH3
Other name(s): CDAT8
Systematic name: tRNA(cytosine8) aminohydrolase
Comments: The enzyme from Methanopyrus kandleri specifically catalyses the deamimation of cytosine at poition 8 of tRNA in 30 different tRNAs. This cytosine-to-uracil editing guarantees the proper folding and functionality of the tRNAs.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Randau, L., Stanley, B.J., Kohlway, A., Mechta, S., Xiong, Y. and Söll, D. A cytidine deaminase edits C to U in transfer RNAs in Archaea. Science 324 (2009) 657–659. [PMID: 19407206]
[EC 3.5.4.35 created 2013]
 
 


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