The enzyme catalyses the second step in archaeal riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis. The first step is catalysed by EC 22.214.171.124 (GTP cyclohydrolase IIa). The bacterial enzyme, EC 126.96.36.199 (GTP cyclohydrolase II) catalyses both reactions.
Grochowski, L.L., Xu, H. and White, R.H. An iron(II) dependent formamide hydrolase catalyzes the second step in the archaeal biosynthetic pathway to riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin. Biochemistry48 (2009) 4181–4188. [DOI] [PMID: 19309161]