The Enzyme Database

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Accepted name: trimerelysin II
Reaction: Cleavage of Asn3┼Gln, His10┼Leu and Ala14┼Leu in the insulin B chain, and the bond Z-Gly-Pro┼Leu-Gly-Pro in a small molecule substrate of microbial collagenase
Other name(s): Trimeresurus metalloendopeptidase II; proteinase H2; H2-proteinase
Comments: A 24 kDa nonhemorrhagic endopeptidase from the venom of the habu snake (Trimeresurus flavoviridis). In peptidase family M12 (astacin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 151125-15-4
1.  Takahashi, T. and Ohsaka, A. Purification and characterization of a proteinase in the venom of Trimeresurus flavoviridis. Complete separation of the enzyme from hemorrhagic activity. Biochim. Biophys. Acta 198 (1970) 293–307. [PMID: 4984550]
2.  Takeya, H., Arakawa, M., Miyata, T., Iwanaga, S. and Omori-Satoh, T. Primary structure of H2-proteinase, a non-hemorrhagic metalloproteinase, isolated from the venom of the habu snake, Trimeresurus flavoviridis. J. Biochem. (Tokyo) 106 (1989) 151–157. [PMID: 2777746]
[EC created 1992]

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