The Enzyme Database

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EC 3.4.24.46     
Accepted name: adamalysin
Reaction: Cleavage of Phe1┼Val, His5┼Leu, His10┼Leu, Ala14┼Leu, Leu15┼Tyr, and Tyr16┼Leu of insulin B chain
Other name(s): Crotalus adamanteus metalloendopeptidase; proteinase I and II; Crotalus adamanteus venom proteinase II; adamalysin II
Comments: From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate α1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 74812-51-4
References:
1.  Kurecki, T., Laskowski, M., Sr. and Kress, L.F. Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human α1-proteinase inhibitor. J. Biol. Chem. 253 (1978) 8340–8345. [PMID: 309470]
[EC 3.4.24.46 created 1992]
 
 


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