The Enzyme Database

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EC 3.4.23.48     
Accepted name: plasminogen activator Pla
Reaction: Converts human Glu-plasminogen to plasmin by cleaving the Arg560┼Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins
Comments: In peptidase family A26. From the bacterium Yersinia pestis that causes plague.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, SWISSPROT, CAS registry number: 101028-08-4
References:
1.  Kukkonen, M., Lähteenmäki, K., Suomalainen, M., Kalkkinen, N., Emödy, L., Laang, H. and Korhonen, T.K. Protein regions important for plasminogen activation and inactivation of α2-antiplasmin in the surface protease Pla of Yersinia pestis. Mol. Microbiol. 40 (2001) 1097–1111. [PMID: 11401715]
[EC 3.4.23.48 created 2003]
 
 


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