ExplorEnz: EC 3.4.23.46

Your query returned 1 entry. Printable version

3.4.23.46

Accepted name:

memapsin 2

Reaction:

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu┼Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer'''s amyloid precursor protein

Other name(s):

β-secretase; β-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)

Comments:

Suggested to be the major "β-secretase" responsible for the cleavage of the β-amyloid precursor protein to form the amyloidogenic β-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 158736-49-3

References:

1.	Turner, R.T., III, K oelsch, G., Hong, L., Castenheira, P., Ghosh, A. and Tang, J. Subsite specificity of memapsin 2 (β-secretase): implications for inhibitor design. Biochemistry 40 (2001) 10001–10006. [DOI] [PMID: 11513577]
2.	Hong, L., Turner, R.T., Koelsch, G., Shin, D., Ghosh, A.K. and Tang, J. Crystal structure of memapsin 2 (β-secretase) in complex with an inhibitor OM00-3. Biochemistry 41 (2002) 10963–10967. [DOI] [PMID: 12206667]

[EC 3.4.23.46 created 2003]