The Enzyme Database

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EC 3.4.23.4     
Accepted name: chymosin
Reaction: Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe105┼Met-Ala bond in κ-chain of casein
Other name(s): rennin (but this should be avoided since it leads to confusion with renin)
Comments: Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family)
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9001-98-3
References:
1.  Foltmann, B. A review of prorennin and rennin. C. R. Trav. Lab. Carlsberg 35 (1966) 143–231. [PMID: 5330666]
2.  Harris, T.J.R., Lowe, P.A., Lyons, A., Thomas, P.G., Eaton, M.A.W., Millican, T.A., Patel, T.P., Bose, C.C., Carey, N.H. and Doel, M.T. Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin. Nucleic Acids Res. 10 (1982) 2177–2187. [PMID: 6283469]
3.  Visser, S., Slangen, C.J. and van Rooijen, P.J. Peptide substrates for chymosin (rennin). Interaction sites in κ-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft. Biochem. J. 244 (1987) 553–558. [PMID: 3128264]
[EC 3.4.23.4 created 1961 as EC 3.4.4.3, transferred 1972 to EC 3.4.23.4, modified 1986]
 
 


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