The Enzyme Database

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EC 3.4.23.16     
Accepted name: HIV-1 retropepsin
Reaction: Specific for a P1 residue that is hydrophobic, and P1′ variable, but often Pro
Other name(s): human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease
Comments: Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses [1]. Type example of peptidase family A2
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 144114-21-6
References:
1.  Kuo, L.C. and Shafer, J.A. (eds) Retroviral Proteases. Methods Enzymol. 241 (1994) 1–431.
2.  Dunn, B.M. Human immunodeficiency virus 1 retropepsin. In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, pp. 919–928.
[EC 3.4.23.16 created 1992, modified 2000]
 
 


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