| EC |
3.4.23.16 |
| Accepted name: |
HIV-1 retropepsin |
| Reaction: |
Specific for a P1 residue that is hydrophobic, and P1′ variable, but often Pro |
| Other name(s): |
human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease |
| Comments: |
Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses [1]. Type example of peptidase family A2 |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 144114-21-6 |
| References: |
| 1. |
Kuo, L.C. and Shafer, J.A. (eds) Retroviral Proteases. Methods Enzymol. 241 (1994) 1–431. |
| 2. |
Dunn, B.M. Human immunodeficiency virus 1 retropepsin. In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Ed.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, pp. 919–928. |
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| [EC 3.4.23.16 created 1992, modified 2000] |
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