||This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 188.8.131.52) and caspase-4 (EC 184.108.40.206) in humans and caspase-11 (EC 220.127.116.11), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [3,5,6]. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but is very inefficient at generating mature interleukin-1β (IL-1β) from pro-IL-1β [1,4]. Both this enzyme and caspase-4 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17) . Unlike caspase-4, this enzyme can be induced by lipopolysaccharide . Belongs in peptidase family C14.
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