| EC |
3.4.22.35 |
| Accepted name: |
histolysain |
| Reaction: |
Hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg┼ in small molecule substrates including Z-Arg-Arg┼NHMec |
| Other name(s): |
histolysin; Entamoeba histolytica cysteine proteinase; amebapain; Entamoeba histolytica cysteine protease; Entamoeba histolytica neutral thiol proteinase |
| Comments: |
From the protozoan, Entamoeba histolytica. In peptidase family C1 (papain family) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 92228-52-9 |
| References: |
| 1. |
Lushbaugh, W.B., Hofbauer, A.F. and Pittman, F.E. Entamoeba histolytica: purification of cathepsin B. Exp. Parasitol. 59 (1985) 328–336. [PMID: 2860002] |
| 2. |
Luaces, A.L. and Barrett, A.J. Affinity purification and biochemical characterization of histolysin: the major cysteine proteinase of Entamoeba histolytica. Biochem. J. 250 (1988) 903–909. [PMID: 2898937] |
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| [EC 3.4.22.35 created 1992] |
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