The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 3.4.21.73     
Accepted name: u-plasminogen activator
Reaction: Specific cleavage of Arg┼Val bond in plasminogen to form plasmin
Other name(s): urokinase; urinary plasminogen activator; cellular plasminogen activator; urokinase-type plasminogen activator; double-chain urokinase-type plasminogen activator; two-chain urokinase-type plasminogen activator; urokinase plasminogen activator; uPA; u-PA; abbokinase; urinary esterase A
Comments: Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from t-plasminogen activator (EC 3.4.21.68), and does not bind to fibrin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.31 and EC 3.4.99.26
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9039-53-6
References:
1.  Lottenberg, R., Christiansen, U., Jackson, C.M. and Coleman, P.L. Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates. Methods Enzymol. 80 (1981) 341–361. [PMID: 6210826]
2.  Loskutoff, D.J. and Schleef, R.R. Plasminogen activators and their inhibitors. Methods Enzymol. 163 (1988) 293–302. [PMID: 3148826]
3.  Saksela, O. and Rifkin, D.B. Cell-associated plasminogen activation: regulation and physiological functions. Annu. Rev. Cell Biol. 4 (1988) 93–126. [PMID: 3143380]
4.  Collen, D., Lijnen, H. R. and Verstraete, M. The fibrinolytic system and its disorders. In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds), Blood: Principles and Practice of Hematology, 2nd edn, J.B.Lippincott Company, Philadelphia, 1990.
5.  Lijnen, H.R., Van Hoef, B., Nelles, L. and Collen, D. Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740→Glu). J. Biol. Chem. 265 (1990) 5232–5236. [PMID: 1969415]
[EC 3.4.21.73 created 1972 as EC 3.4.99.26, transferred 1978 as EC 3.4.21.31, part transferred 1992 to EC 3.4.21.73]
 
 


Data © 2001–2014 IUBMB
Web site © 2005–2014 Andrew McDonald