The Enzyme Database

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EC 3.4.21.55     
Accepted name: venombin AB
Reaction: Selective cleavage at Arg┼ bonds in fibrinogen to form fibrin and release fibrinopeptides A and B
Other name(s): gabonase; okinaxobin II; Bitis gabonica venom serine proteinase; afaâcytin
Comments: From the venom of the Gaboon viper Bitis gabonica. Activates Factor XIII. Not inhibited by antithrombin III/heparin or hirudin, unlike EC 3.4.21.5, thrombin
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 104003-74-9
References:
1.  Pirkle, H., Theodor, I., Miyada, D. and Simmons, G. Thrombin-like enzyme from the venom of Bitis gabonica. Purification, properties and coagulant actions. J. Biol. Chem. 261 (1986) 8830–8835. [PMID: 3522580]
[EC 3.4.21.55 created 1989]
 
 


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