The Enzyme Database

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EC 3.4.14.2     
Accepted name: dipeptidyl-peptidase II
Reaction: Release of an N-terminal dipeptide, Xaa-Yaa┼, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides
Other name(s): dipeptidyl aminopeptidase II; dipeptidyl arylamidase II; carboxytripeptidase; dipeptidyl peptidase II; dipeptidyl arylamidase II; DAP II; dipeptidyl(amino)peptidase II; dipeptidylarylamidase
Comments: A lysosomal serine-type peptidase in family S28 (Pro-X carboxypeptidase family); maximally active at acidic pH
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, CAS registry number: 76199-23-0
References:
1.  McDonald, J.K., Reilly, T.J., Zeitman, B.B. and Ellis, S. Dipeptidyl arylamidase II of the pituitary. Properties of lysyl-alanyl-β-naphthylamide hydrolysis: inhibition by cations, distribution in tissues and subcellular localization. J. Biol. Chem. 243 (1968) 4143–4150. [PMID: 4969969]
2.  McDonald, J.K. and Schwabe, C. Intracellular exopeptidases. In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, pp. 311–391.
[EC 3.4.14.2 created 1978]
 
 


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