The Enzyme Database

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EC 3.4.13.20     
Accepted name: β-Ala-His dipeptidase
Reaction: Preferential hydrolysis of the β-Ala┼His dipeptide (carnosine), and also anserine, Xaa┼His dipeptides and other dipeptides including homocarnosine
Other name(s): serum carnosinase
Comments: Present in the serum of humans and higher primates, but not in the serum of other mammals. Activated by Cd2+ and citrate. Belongs in peptidase family M20.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 525589-43-9
References:
1.  Lenney, J.F., George, R.P., Weiss, A.M., Kucera, C.M., Chan, P.W.H. and Rinzler, G.S. Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium. Clin. Chim. Acta 123 (1982) 221–231. [PMID: 7116644]
2.  Jackson, M.C., Kucera, C.M. and Lenney, J.F. Purification and properties of human serum carnosinase. Clin. Chim. Acta 196 (1991) 193–206. [PMID: 1903095]
[EC 3.4.13.20 created 1992]
 
 


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