The Enzyme Database

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EC 3.4.11.21     
Accepted name: aspartyl aminopeptidase
Reaction: Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate
Comments: Aminoacyl-arylamides are poor substrates. This is an abundant cytosolic enzyme in mammalian cells, in peptidase family M18 of aminopeptidase I
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 9074-83-3
References:
1.  Kelly, J.A., Neidle, E.L. and Neidle, A. An aminopeptidase from mouse brain cytosol that cleaves N-terminal acidic amino acid residues. J. Neurochem. 40 (1983) 1727–1734. [DOI] [PMID: 6854330]
2.  Wilk, S., Wilk, E. and Magnusson, R.P. Purification, characterization and cloning of a cytosolic aspartyl aminopeptidase. J. Biol. Chem. 273 (1998) 15961–15970. [DOI] [PMID: 9632644]
[EC 3.4.11.21 created 2000]
 
 


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