The Enzyme Database

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EC 3.2.1.47     
Accepted name: galactosylgalactosylglucosylceramidase
Reaction: α-D-galactosyl-(1→4)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + H2O = D-galactose + β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide
For diagram of glycolipid biosynthesis, click here
Other name(s): trihexosyl ceramide galactosidase; ceramide trihexosidase; ceramidetrihexoside α-galactosidase; trihexosylceramide α-galactosidase; ceramidetrihexosidase
Systematic name: α-D-galactosyl-(1→4)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide galactohydrolase
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9023-01-2
References:
1.  Brady, R.O., Gal, A.E., Bradley, R.M. and Matensson, E. The metabolism of ceramide trihexosides. I. Purification and properties of an enzyme that cleaves the terminal galactose molecule of galactosylgalactosylglucosylceramide. J. Biol. Chem. 242 (1967) 1021–1026. [PMID: 6020428]
2.  Mapes, C.A. and Sweeley, C.C. Substrate specificity of ceramide trihexosidase. FEBS Lett. 25 (1972) 279–281. [PMID: 11946769]
[EC 3.2.1.47 created 1972, modified 2011]
 
 


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