The Enzyme Database

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EC 3.2.1.35     
Accepted name: hyaluronoglucosaminidase
Reaction: Random hydrolysis of (1→4)-linkages between N-acetyl-β-D-glucosamine and D-glucuronate residues in hyaluronate
Other name(s): hyaluronidase; hyaluronoglucosidase; chondroitinase; chondroitinase I
Systematic name: hyaluronate 4-glycanohydrolase
Comments: Also hydrolyses 1,4-β-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37326-33-3
References:
1.  Meyer, K., Hoffman, P. and Linker, A. Hyaluronidases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds), The Enzymes, 2nd edn, vol. 4, Academic Press, New York, 1960, pp. 447–460.
2.  Rapport, M.M., Myer, K. and Linker, A. Analysis of the products formed on hydrolysis of hyaluronic acid by testicular hyaluronidase. J. Am. Chem. Soc. 73 (1951) 2416–2420.
3.  Weissmann, B. The transglycosylative action of testicular hyaluronidase. J. Biol. Chem. 216 (1955) 783–794. [PMID: 13271353]
[EC 3.2.1.35 created 1965, modified 1976, modified 2001 (EC 3.2.1.34 created 1965, incorporated 1972)]
 
 


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