EC |
3.2.1.221 |
Accepted name: |
MMP endo-(1,4)-3-O-methyl-α-D-mannosidase |
Reaction: |
Endohydrolysis of 3-O-methyl-α-D-mannosyl-(1→4)-3-O-methyl-D-mannose linkages within (1,4)-3-O-methyl-α-D-mannnan substrates |
Glossary: |
MMP = 3-O-methylmannose polysaccharide = α-D-mannosyl-(1→4)-[3-O-methyl-α-D-mannosyl-(1→4)]n-1-O,3-O-dimethyl-α-D-mannose |
Other name(s): |
MMP α-(1→4)-endomannosidase; mmpH (gene name) |
Systematic name: |
(1,4)-3-O-methyl-α-D-mannan 4-α-3-O-methyl-D-mannohydrolase |
Comments: |
The enzyme, present in mycobacterial species that produce 3-O-methylmannose polysaccharide (MMP), is involved in recycling and biosynthesis of the polymer. The enzyme has been shown to cleave substrates in the range of 11–14 mannose residues. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Maranha, A., Costa, M., Ripoll-Rozada, J., Manso, J.A., Miranda, V., Mendes, V.M., Manadas, B., Macedo-Ribeiro, S., Ventura, M.R., Pereira, P.JB. and Empadinhas, N. Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides. Commun Biol 6:108 (2023). [DOI] [PMID: 36707645] |
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[EC 3.2.1.221 created 2023] |
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