ExplorEnz: EC 3.1.3.85

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3.1.3.85

Accepted name:

glucosyl-3-phosphoglycerate phosphatase

Reaction:

2-O-(α-D-glucopyranosyl)-3-phospho-D-glycerate + H₂O = 2-O-(α-D-glucopyranosyl)-D-glycerate + phosphate

Other name(s):

GpgP protein

Systematic name:

α-D-glucosyl-3-phospho-D-glycerate phosphohydrolase

Comments:

The enzyme is involved in biosynthesis of 2-O-(α-D-glucopyranosyl)-D-glycerate via the two-step pathway in which EC 2.4.1.266 (glucosyl-3-phosphoglycerate synthase) catalyses the conversion of GDP-glucose and 3-phospho-D-glycerate into 2-O-(α-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(α-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase. In vivo the enzyme catalyses the dephosphorylation of 2-O-(α-D-mannopyranosyl)-3-phospho-D-glycerate with lower efficiency [1,2]. Divalent metal ions (Mg²⁺, Mn²⁺ or Co²⁺) stimulate activity [1,2].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Costa, J., Empadinhas, N. and da Costa, M.S. Glucosylglycerate biosynthesis in the deepest lineage of the bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina. J. Bacteriol. 189 (2007) 1648–1654. [DOI] [PMID: 17189358]
2.	Costa, J., Empadinhas, N., Goncalves, L., Lamosa, P., Santos, H. and da Costa, M.S. Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii. J. Bacteriol. 188 (2006) 1022–1030. [DOI] [PMID: 16428406]
3.	Mendes, V., Maranha, A., Alarico, S., da Costa, M.S. and Empadinhas, N. Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis. Sci. Rep. 1:177 (2011). [DOI] [PMID: 22355692]

[EC 3.1.3.85 created 2011]