The Enzyme Database

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EC 3.1.26.11     
Accepted name: tRNase Z
Reaction: endonucleolytic cleavage of RNA, removing extra 3′ nucleotides from tRNA precursor, generating 3′ termini of tRNAs. A 3′-hydroxy group is left at the tRNA terminus and a 5′-phosphoryl group is left at the trailer molecule
Other name(s): 3 tRNase; tRNA 3 endonuclease; RNase Z; 3′ tRNase
Comments: No cofactor requirements. An homologous enzyme to that found in Arabidopsis thaliana has been found in Methanococcus janaschii.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 98148-84-6
References:
1.  Schiffer, S., Rösch, S. and Marchfelder, A. Assigning a function to a conserved group of proteins: the tRNA 3′-processing enzymes. EMBO J. 21 (2002) 2769–2777. [PMID: 12032089]
2.  Mayer, M., Schiffer, S. and Marchfelder, A. tRNA 3′ processing in plants: nuclear and mitochondrial activities differ. Biochemistry 39 (2000) 2096–2105. [PMID: 10684660]
3.  Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. and Marchfelder, A. The plant tRNA 3′ processing enzyme has a broad substrate spectrum. Biochemistry 40 (2001) 8264–8272. [PMID: 11444972]
4.  Kunzmann, A., Brennicke, A. and Marchfelder, A. 5′ end maturation and RNA editing have to precede tRNA 3′ processing in plant mitochondria. Proc. Natl. Acad. Sci. USA 95 (1998) 108–113. [PMID: 9419337]
5.  Mörl, M. and Marchfelder, A. The final cut. The importance of tRNA 3′-processing. EMBO Rep. 2 (2001) 17–20. [PMID: 11252717]
6.  Minagawa, A., Takaku, H., Takagi, M. and Nashimoto, M. A novel endonucleolytic mechanism to generate the CCA 3′ termini of tRNA molecules in Thermotoga maritima. J. Biol. Chem. 279 (2004) 15688–15697. [PMID: 14749326]
7.  Takaku, H., Minagawa, A., Takagi, M. and Nashimoto, M. A candidate prostate cancer susceptibility gene encodes tRNA 3′ processing endoribonuclease. Nucleic Acids Res. 31 (2003) 2272–2278. [PMID: 12711671]
[EC 3.1.26.11 created 2002]
 
 


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