The Enzyme Database

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EC 3.1.21.6     
Accepted name: CC-preferring endodeoxyribonuclease
Reaction: endonucleolytic cleavage to give 5′-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC
Other name(s): Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease
Comments: Prefers CC sites in double-stranded circular and linear DNA. Greater affinity for double-stranded than single-stranded DNA. Produces nicks, generating double-stranded fragments with 5′- and/or 3′-protruding single-stranded tails. Requires magnesium ions for activity. The endonuclease from Chlorella-like green algae infected with NYs-1 virus 4[1] may be the same enzyme.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37211-67-9
References:
1.  Xia, Y.N., Morgan, R., Schildkraut, I., Van Etten, J.L. A site-specific single-strand endonuclease activity induced by NYs-1 virus-infection of a Chlorella-like green-alga. Nucleic Acids Res. 16 (1988) 9477–9487. [PMID: 3186439]
2.  Aparicio, J.F., Lopez-Otin, C., Cal, S., Sanchez, J. A Streptomyces glaucescens endodeoxyribonuclease which shows a strong preference for CC dinucleotide. Eur. J. Biochem. 205 (1992) 695–699. [PMID: 1533367]
[EC 3.1.21.6 created 1999]
 
 


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