| EC |
3.1.2.15 |
| Accepted name: |
ubiquitin thiolesterase |
| Reaction: |
ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol |
| Other name(s): |
ubiquitin carboxy-terminal esterase; isopeptidase (misleading); isopeptidase T (misleading); ubiquitin C-terminal hydrolase; ubiquitin carboxy-terminal hydrolase; ubiquitin-C-terminal-thiolester hydrolase |
| Systematic name: |
ubiquitin-C-terminal-thioester hydrolase |
| Comments: |
Acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin. May be the same as EC 3.4.19.12, ubiquitinyl hydrolase 1. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, METACYC, PDB, CAS registry number: 86480-67-3 |
| References: |
| 1. |
Rose, I.A. and Warms, J.V.B. An enzyme with ubiquitin carboxy-terminal esterase activity from reticulocytes. Biochemistry 22 (1983) 4234–4237. [PMID: 6313036] |
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| [EC 3.1.2.15 created 1986] |
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