The Enzyme Database

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Accepted name: ubiquitin thiolesterase
Reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol
Other name(s): ubiquitin carboxy-terminal esterase; isopeptidase (misleading); isopeptidase T (misleading); ubiquitin C-terminal hydrolase; ubiquitin carboxy-terminal hydrolase; ubiquitin-C-terminal-thiolester hydrolase
Systematic name: ubiquitin-C-terminal-thioester hydrolase
Comments: Acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin. May be the same as EC, ubiquitinyl hydrolase 1.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 86480-67-3
1.  Rose, I.A. and Warms, J.V.B. An enzyme with ubiquitin carboxy-terminal esterase activity from reticulocytes. Biochemistry 22 (1983) 4234–4237. [PMID: 6313036]
[EC created 1986]

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