The Enzyme Database

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EC 3.1.11.3     
Accepted name: exodeoxyribonuclease (lambda-induced)
Reaction: Exonucleolytic cleavage in the 5′- to 3′-direction to yield nucleoside 5′-phosphates
Other name(s): lambda exonuclease; phage lambda-induced exonuclease; Escherichia coli exonuclease IV; E. coli exonuclease IV; exodeoxyribonuclease IV; exonuclease IV
Comments: Preference for double-stranded DNA. Does not attack single-strand breaks.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37367-70-7
References:
1.  Lindahl, T., Gally, J.A. and Edelman, G.M. Deoxyribonuclease IV: a new exonuclease from mammalian tissues. Proc. Natl. Acad. Sci. USA 62 (1969) 597–603. [PMID: 5256235]
2.  Little, J.W. An exonuclease induced by bacteriophage lambda. II. Nature of the enzymatic reaction. J. Biol. Chem. 242 (1967) 679–686. [PMID: 6017737]
[EC 3.1.11.3 created 1972 as EC 3.1.4.28, transferred 1978 to EC 3.1.11.3]
 
 


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