The Enzyme Database

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EC 3.1.11.1     
Accepted name: exodeoxyribonuclease I
Reaction: Exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates
Other name(s): Escherichia coli exonuclease I; E. coli exonuclease I; exonuclease I
Comments: Preference for single-stranded DNA. The Escherichia coli enzyme hydrolyses glucosylated DNA.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9037-46-1
References:
1.  Blakesley, R.W., Dodgson, J.B., Nes, I.F. and Wells, R.D. Duplex regions in single-stranded phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius. J. Biol. Chem. 252 (1977) 7300–7306. [PMID: 71298]
2.  Kelley, R.B., Atkinson, M.R., Huberman, J.A. and Kornberg, A. Excision of thymine dimers and other mismatched sequences by DNA polymerases of Escherichia coli. Nature 224 (1969) 495–501.
3.  Lehman, I.R. and Nussbaum, A.L. The deoxyribonucleases of Escherichia coli. V. On the specificity of exonuclease I (phosphodiesterase). J. Biol. Chem. 239 (1964) 2628–2636. [PMID: 14235546]
[EC 3.1.11.1 created 1972 as EC 3.1.4.25, transferred 1978 to EC 3.1.11.1]
 
 


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