ExplorEnz: EC 3.1.1.34

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3.1.1.34

Accepted name:

lipoprotein lipase

Reaction:

triacylglycerol + H₂O = diacylglycerol + a carboxylate

Other name(s):

clearing factor lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor; hepatic triacylglycerol lipase; LIPC (gene name); LPL (gene name); triacylglycero-protein acylhydrolase

Systematic name:

triacylglycerol acylhydrolase (lipoprotein-dependent)

Comments:

Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles. Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride → 1,2-diglyceride → 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9004-02-8

References:

1.	Egelrud, T. and Olivecrona, T. Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors. Biochim. Biophys. Acta 306 (1973) 115–127. [DOI] [PMID: 4703566]
2.	Fielding, C.J. Human lipoprotein lipase. I. Purification and substrate specificity. Biochim. Biophys. Acta 206 (1970) 109–117. [DOI] [PMID: 5441398]
3.	Greten, H., Levy, R.I., Fales, H. and Fredrickson, D.S. Hydrolysis of diglyceride and glyceryl monoester diethers with lipoprotein lipase. Biochim. Biophys. Acta 210 (1970) 39–45. [DOI] [PMID: 5466051]
4.	Morley, N. and Kuksis, A. Positional specificity of lipoprotein lipase. J. Biol. Chem. 247 (1972) 6389–6393. [PMID: 5076762]
5.	Nilsson-Ehle, P., Belfrage, P. and Borgström, B. Purified human lipoprotein lipase: positional specificity. Biochim. Biophys. Acta 248 (1971) 114–120. [DOI] [PMID: 5168777]
6.	Santamarina-Fojo, S., Gonzalez-Navarro, H., Freeman, L., Wagner, E. and Nong, Z. Hepatic lipase, lipoprotein metabolism, and atherogenesis. Arterioscler Thromb Vasc Biol 24 (2004) 1750–1754. [PMID: 15284087]

[EC 3.1.1.34 created 1972, modified 1976]