The Enzyme Database

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EC 2.8.3.8     
Accepted name: acetate CoA-transferase
Reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA
Other name(s): acetate coenzyme A-transferase; butyryl CoA:acetate CoA transferase; butyryl coenzyme A transferase; succinyl-CoA:acetate CoA transferase
Systematic name: acyl-CoA:acetate CoA-transferase
Comments: The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism. The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue. Unlike EC 2.8.3.9, butyrate—acetoacetate CoA-transferase, this enzyme exhibits maximal activity using acetate as the CoA acceptor. Substrate range depends on the specific enzyme. Typical substrates include butanoyl-CoA and pentanoyl-CoA.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, UM-BBD, CAS registry number: 37278-35-6
References:
1.  Vanderwinkel, E., Furmanski, P., Reeves, H.C. and Ajl, S.J. Growth of Escherichia coli on fatty acids: requirement for coenzyme A transferase activity. Biochem. Biophys. Res. Commun. 33 (1968) 902–908. [PMID: 4884054]
2.  Rangarajan, E.S., Li, Y., Ajamian, E., Iannuzzi, P., Kernaghan, S.D., Fraser, M.E., Cygler, M. and Matte, A. Crystallographic trapping of the glutamyl-CoA thioester intermediate of family I CoA transferases. J. Biol. Chem. 280 (2005) 42919–42928. [PMID: 16253988]
[EC 2.8.3.8 created 1972]
 
 


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