The Enzyme Database

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EC 2.8.2.36     
Accepted name: desulfo-A47934 sulfotransferase
Reaction: 3′-phosphoadenylyl sulfate + desulfo-A47934 = adenosine 3′,5′-bisphosphate + A47934
Glossary: desulfo-A47934 = LY 154989 = 7-demethyl-64-O-demethyl-19-deoxy-22,31,45-trichloro-11-sulfo-ristomycin A aglycone
Other name(s): StaL
Systematic name: 3′-phosphoadenylyl-sulfate:desulfo-A47934 sulfotransferase
Comments: The enzyme from the bacterium Streptomyces toyocaensis catalyses the final step in the biosynthesis of the glycopeptide antibiotic A47934, a naturally occuring antibiotic of the vancomycin group.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Lamb, S.S., Patel, T., Koteva, K.P. and Wright, G.D. Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL. Chem. Biol. 13 (2006) 171–181. [PMID: 16492565]
2.  Shi, R., Lamb, S.S., Bhat, S., Sulea, T., Wright, G.D., Matte, A. and Cygler, M. Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis. J. Biol. Chem. 282 (2007) 13073–13086. [PMID: 17329243]
[EC 2.8.2.36 created 2014]
 
 


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