The Enzyme Database

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EC 2.7.7.91     
Accepted name: valienol-1-phosphate guanylyltransferase
Reaction: GTP + valienol 1-phosphate = diphosphate + GDP-valienol
For diagram of validamycin biosynthesis, click here
Glossary: valienol 1-phosphate = (1S,4R,5S,6R)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl phosphate
Other name(s): vldB (gene name)
Systematic name: GTP:valienol 1-phosphate guanylyltransferase
Comments: The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Yang, J., Xu, H., Zhang, Y., Bai, L., Deng, Z. and Mahmud, T. Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis. Org. Biomol. Chem. 9 (2011) 438–449. [PMID: 20981366]
2.  Asamizu, S., Yang, J., Almabruk, K.H. and Mahmud, T. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. J. Am. Chem. Soc. 133 (2011) 12124–12135. [PMID: 21766819]
[EC 2.7.7.91 created 2016]
 
 


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