The Enzyme Database

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EC 2.7.7.49     
Accepted name: RNA-directed DNA polymerase
Reaction: a 2′-deoxyribonucleoside 5′-triphosphate + DNAn = diphosphate + DNAn+1
Other name(s): DNA nucleotidyltransferase (RNA-directed); reverse transcriptase; revertase; RNA-dependent deoxyribonucleate nucleotidyltransferase; RNA revertase; RNA-dependent DNA polymerase; RNA-instructed DNA polymerase; RT
Systematic name: 2′-deoxyribonucleoside-5′-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed)
Comments: Catalyses RNA-template-directed extension of the 3′- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC 2.7.7.7 DNA-directed DNA polymerase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9068-38-6
References:
1.  Baltimore, D. RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature 226 (1970) 1209–1211. [PMID: 4316300]
2.  Temin, H. and Mizutani, S. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature 226 (1970) 1211–1213. [PMID: 4316301]
[EC 2.7.7.49 created 1981, modified 1982]
 
 


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