| EC |
2.7.6.3 |
| Accepted name: |
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase |
| Reaction: |
ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate |
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For diagram of the late stages of folate biosynthesis, click here |
| Other name(s): |
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; H2-pteridine-CH2OH pyrophosphokinase; 7,8-dihydroxymethylpterin-pyrophosphokinase; HPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; hydroxymethyldihydropteridine pyrophosphokinase |
| Systematic name: |
ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6′-diphosphotransferase |
| Links to other databases: |
BRENDA, EXPASY, KEGG, METACYC, PDB, CAS registry number: 37278-23-2 |
| References: |
| 1. |
Richey, D.P. and Brown, G.M. The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid. J. Biol. Chem. 244 (1969) 1582–1592. [PMID: 4304228] |
| 2. |
Richey, D.P. and Brown, G.M. Hydroxymethyldihydropteridine pyrophosphokinase and dihydropteroate synthetase from Escherichia coli. Methods Enzymol. 18B (1971) 765–771. |
| 3. |
Shiota, T., Baugh, C.M., Jackson, R. and Dillard, R. The enzymatic synthesis of hydroxymethyldihydropteridine pyrophosphate and dihydrofolate. Biochemistry 8 (1969) 5022–5028. [PMID: 4312465] |
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| [EC 2.7.6.3 created 1972] |
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