The Enzyme Database

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EC 2.7.4.7     
Accepted name: phosphooxymethylpyrimidine kinase
Reaction: ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
For diagram of thiamine diphosphate biosynthesis, click here
Glossary: 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = (4-amino-2-methylpyrimidin-5-yl)methyl dihydrogen phosphate
Other name(s): hydroxymethylpyrimidine phosphokinase; ATP:4-amino-2-methyl-5-phosphooxymethylpyrimidine phosphotransferase; ATP:(4-amino-2-methylpyrimidin-5-yl)methyl-phosphate phosphotransferase; phosphomethylpyrimidine kinase
Systematic name: ATP:4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine phosphotransferase
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37278-18-5
References:
1.  Lewin, L.M. and Brown, G.M. The biosynthesis of thiamine. III. Mechanism of enzymatic formation of the pyrophosphate ester of 2-methyl-4-amino-5-hydroxymethylpyrimidine. J. Biol. Chem. 236 (1961) 2768–2771.
[EC 2.7.4.7 created 1965, modified 2016]
 
 


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