EC |
2.7.4.34 |
Accepted name: |
GDP-polyphosphate phosphotransferase |
Reaction: |
GTP + (phosphate)n = GDP + (phosphate)n+1 |
Other name(s): |
ppk2 (gene name); polyphosphate kinase 2 |
Systematic name: |
GTP:polyphosphate phosphotransferase |
Comments: |
Polyphosphate kinase 2, characterized from the bacterium Pseudomonas aeruginosa, uses inorganic polyphosphate as a donor to convert GDP to GTP. The enzyme can also act on ADP (cf. EC 2.7.4.1, ATP-polyphosphate phosphotransferase), but with lower activity. The enzyme has only a trivial activity in the opposite direction (synthesizing polyphosphate from GTP). The GTP that is produced is believed to be consumed by EC 2.7.7.13, mannose-1-phosphate guanylyltransferase, for production of alginate during stationary phase. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Zhang, H., Ishige, K. and Kornberg, A. A polyphosphate kinase (PPK2) widely conserved in bacteria. Proc. Natl. Acad. Sci. USA 99 (2002) 16678–16683. [DOI] [PMID: 12486232] |
2. |
Ishige, K., Zhang, H. and Kornberg, A. Polyphosphate kinase (PPK2), a potent, polyphosphate-driven generator of GTP. Proc. Natl. Acad. Sci. USA 99 (2002) 16684–16688. [DOI] [PMID: 12482933] |
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[EC 2.7.4.34 created 2021] |
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