This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
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Li, W., Simarro, M., Kedersha, N. and Anderson, P. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. Mol. Cell. Biol.24 (2004) 10718–10732. [PMID: 15572676]
[EC 126.96.36.199 created 2005 (EC 188.8.131.52 part-incorporated 2005)]