The Enzyme Database

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EC 2.7.11.30     
Accepted name: receptor protein serine/threonine kinase
Reaction: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Other name(s): activin receptor kinase; receptor type I serine/threonine protein kinase; receptor type II serine/threonine protein kinase; STK13; TGF-β kinase; receptor serine/threonine protein kinase
Systematic name: ATP:[receptor-protein] phosphotransferase
Comments: The transforming growth factor β (TGF-β) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-β is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDF
References:
1.  Wrana, J.L., Attisano, L., Wieser, R., Ventura, F. and Massagué, J. Mechanism of activation of the TGF-β receptor. Nature 370 (1994) 341–347. [PMID: 8047140]
2.  Massagué, J. and Chen, Y.G. Controlling TGF-β signaling. Gene 14 (2000) 627–644. [PMID: 10733523]
3.  de Caestecker, M.P., Hemmati, P., Larisch-Bloch, S., Ajmera, R., Roberts, A.B. and Lechleider, R.J. Characterization of functional domains within Smad4/DPC4. J. Biol. Chem. 272 (1997) 13690–13696. [PMID: 9153220]
[EC 2.7.11.30 created 2005 (EC 2.7.1.37 part-incorporated 2005)]
 
 


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