| EC |
2.7.11.30 |
| Accepted name: |
receptor protein serine/threonine kinase |
| Reaction: |
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate |
| Other name(s): |
activin receptor kinase; receptor type I serine/threonine protein kinase; receptor type II serine/threonine protein kinase; STK13; TGF-β kinase; receptor serine/threonine protein kinase |
| Systematic name: |
ATP:[receptor-protein] phosphotransferase |
| Comments: |
The transforming growth factor β (TGF-β) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-β is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Wrana, J.L., Attisano, L., Wieser, R., Ventura, F. and Massagué, J. Mechanism of activation of the TGF-β receptor. Nature 370 (1994) 341–347. [DOI] [PMID: 8047140] |
| 2. |
Massagué, J. and Chen, Y.G. Controlling TGF-β signaling. Gene 14 (2000) 627–644. [PMID: 10733523] |
| 3. |
de Caestecker, M.P., Hemmati, P., Larisch-Bloch, S., Ajmera, R., Roberts, A.B. and Lechleider, R.J. Characterization of functional domains within Smad4/DPC4. J. Biol. Chem. 272 (1997) 13690–13696. [DOI] [PMID: 9153220] |
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| [EC 2.7.11.30 created 2005 (EC 2.7.1.37 part-incorporated 2005)] |
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